Pleural aspiration is a procedure that involves the insertion of a needle into the pleural space to obtain the fluid or tissue sample. The procedure is usually performed under imaging guidance (ultrasound-guided) to guide the needle precisely to the abnormal tissue site. Pleural aspiration is both a diagnostic and therapeutic procedure. It helps in diagnosing the disease by evaluating the sample in the laboratory. It also relieves the symptoms, such as chest pain, cough, and shortness of breath, by draining the fluid from the pleural space.